Course unit code:
Course unit title:
Organic Chemistry I
Mode of completion and Number of ECTS credits:
Exm (4 credits)
Course contents:
1. Structure and bonding in organic molecules. (allowance 2/2)
a. Ionic and covalent bonds.
b. Atomic, hybrid and molecular orbitals.
c. Electron effects.
d. Kinetics and thermodynamics of organic reactions.

2. Alkanes and cykloalkanes. (allowance 4/4)
a. Structural and physical properties of alkanes .
b. Stability of radicals and radical substitution reactions of alkanes.
c. Conformational analysis of alkanes and cycloalkanes.
d. Stereoisomerism. Enantiomers, diastereoisomers , absolute configuration and Fischer projection.

3. Unsaturated hydrocarbons. (allowance 6/6)
a. Structure, physical properties and reactivity of alkenes. Electrophilic and radical addition reactions. Regioselectivity and diastereoselectivity of reactions.
b. Dienes, delocalized electron systems and energy of conjugation.
c. Electrophilic attack on butadiene, kinetic and thermodynamic control of reaction. Stereoselectivity of cycloaddition reactions.
d. Structure of alkynes, regioselectivity and stereoselectivity of addition reactions. Acid-base reactions of terminal alkynes.

4. Aromatic compounds. (allowance 4/4)
a. Aromaticity and structure of benzene.
b. Electrophilic aromatic substitution of benzene.
c. Effects of substituents on relative rates and regioselectivity of electrophilic attack.
d. Reactions of substituents on benzene ring.

5. Structure and reactivity of alkyl- and arylhalides. (allowance 4/4)
a. Mechanisms and stereochemistry of nucleophilic substitution reactions. Effect of structure of substrate and reaction conditions on the nucleophilic substitution.
b. Elimination reactions E1 and E2.
c. Structure and reactivity of organometallic compounds Mg, Li, Zn and Cu.

6. Hydroxy derivatives. (allowance 6/6)
a. Structure and physical properties of alcohols.
b. Substitution and elimination reactions of alcohols, nucleophilic rearrangements.
c. Structure and reactivity of phenols.
d. Physical properties, structure and reactivity of ethers.
e. Sulfur analogs of alcohols and ethers.

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